Attenuation of Nicotine-Induced Antinociception, Rewarding Effects, and Dependence in -Opioid Receptor Knock-Out Mice
نویسندگان
چکیده
Fernando Berrendero,1 Brigitte L. Kieffer,2 and Rafael Maldonado1 Laboratori de Neurofarmacologia, Facultat de Ciéncies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain, and Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur, BP 163 67404 Illkirch, France
منابع مشابه
Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice.
The involvement of mu-opioid receptors in different behavioral responses elicited by nicotine was explored by using mu-opioid receptor knock-out mice. The acute antinociceptive responses induced by nicotine in the tail-immersion and hot-plate tests were reduced in the mutant mice, whereas no difference between genotypes was observed in the locomotor responses. The rewarding effects induced by n...
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تاریخ انتشار 2002